BDBM50503711 CHEMBL4447072

SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#7]-1-[#6]-[#6]-[#7](-[#6]-c2c(-[#6])n(-[#6])n(-c3ccccc3)c2=O)-[#6]-[#6@@H]-1-[#6]-[#6]-[#8]

InChI Key InChIKey=VVGGJPGAOOQMML-UHFFFAOYSA-N

Data  3 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50503711   

Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Shaanxi Province Tuberculosis Prevention and Treatment Institute

Curated by ChEMBL
LigandPNGBDBM50503711(CHEMBL4447072)
Affinity DataEC50:  4.64E+3nMAssay Description:Inhibition of PDK1 (unknown origin) using PDH E1 as substrate measured after 30 mins by kinase-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Shaanxi Province Tuberculosis Prevention and Treatment Institute

Curated by ChEMBL
LigandPNGBDBM50503711(CHEMBL4447072)
Affinity DataKd:  1.05E+4nMAssay Description:Binding affinity to SUMO-fused/His-tagged PDK1 (unknown origin) expressed in Escherichia coli by isothermal calorimetric titration analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Human)
Shaanxi Province Tuberculosis Prevention and Treatment Institute

Curated by ChEMBL
LigandPNGBDBM50503711(CHEMBL4447072)
Affinity DataKd:  1.59E+4nMAssay Description:Binding affinity to SUMO-fused/His-tagged PDK2 (unknown origin) expressed in Escherichia coli by isothermal calorimetric titration analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial(Human)
Shaanxi Province Tuberculosis Prevention and Treatment Institute

Curated by ChEMBL
LigandPNGBDBM50503711(CHEMBL4447072)
Affinity DataKd:  8.90E+3nMAssay Description:Binding affinity to SUMO-fused/His-tagged PDK3 (unknown origin) expressed in Escherichia coli by isothermal calorimetric titration analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed