BDBM50503462 CHEMBL4527834

SMILES C[C@H]1CN(Cc2cc3nc(cc(-c4ccc(F)cc4)c3s2)C(N)=O)C[C@@H](C)O1

InChI Key InChIKey=CGOSJAXPXSHPEA-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50503462   

TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50503462(CHEMBL4527834)
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of human mGlu5R expressed in Trex293 cells assessed as decrease in glutamate-induced calcium mobilization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50503462(CHEMBL4527834)
Affinity DataIC50: 550nMAssay Description:Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50503462(CHEMBL4527834)
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of rat mGlu3R expressed in Trex cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50503462(CHEMBL4527834)
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of human mGlu6 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50503462(CHEMBL4527834)
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells harboring GIRK assessed as reduction in LPA4-induced thallium flux preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50503462(CHEMBL4527834)
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of rat mGlu8 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50503462(CHEMBL4527834)
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of human mGlu1R expressed in Trex293 cells assessed as decrease in glutamate-induced calcium mobilization preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50503462(CHEMBL4527834)
Affinity DataIC50: 550nMAssay Description:Negative allosteric modulation of rat mGlu2R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50503462(CHEMBL4527834)
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of rat mGlu4 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed