BDBM50503436 CHEMBL4567262::US11274074, Comparative Example 4 [Chemical Formula 22]

SMILES COc1cccc(c1)-c1nnc(COc2ccc(Cl)cc2C)o1

InChI Key InChIKey=HWSMRVPKFALRIV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50503436   

TargetAnoctamin-2(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50503436(CHEMBL4567262 | US11274074, Comparative Example 4 ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of YFP-fused ANO2 (unknown origin) expressed in FRT cells after 20 mins by fluorescence quenching methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAnoctamin-1(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50503436(CHEMBL4567262 | US11274074, Comparative Example 4 ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of YFP-fused ANO1 (unknown origin) expressed in FRT cells after 20 mins by fluorescence quenching methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAnoctamin-1(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50503436(CHEMBL4567262 | US11274074, Comparative Example 4 ...)
Affinity DataIC50: 1.00E+5nMAssay Description:The method for inhibiting the expression of ANO1 (TMEM16A) of the present disclosure includes a step of inhibiting the expression of ANO1 (TMEM16A) i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
Go to US Patent

TargetAnoctamin-2(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50503436(CHEMBL4567262 | US11274074, Comparative Example 4 ...)
Affinity DataIC50: 1.00E+5nMAssay Description:The method for inhibiting the expression of ANO1 (TMEM16A) of the present disclosure includes a step of inhibiting the expression of ANO1 (TMEM16A) i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
Go to US Patent