BDBM50503433 CHEMBL4462374::US11274074, Comparative Example 19 [Chemical Formula 37]

SMILES Cc1cc(Cl)ccc1OC(F)(F)C(=O)N\N=C\c1ccccc1OC(F)(F)F

InChI Key InChIKey=HWTGSBKAKAOBNQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50503433   

TargetAnoctamin-1(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50503433(CHEMBL4462374 | US11274074, Comparative Example 19...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of YFP-fused ANO1 (unknown origin) expressed in FRT cells after 20 mins by fluorescence quenching methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAnoctamin-2(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50503433(CHEMBL4462374 | US11274074, Comparative Example 19...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of YFP-fused ANO2 (unknown origin) expressed in FRT cells after 20 mins by fluorescence quenching methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAnoctamin-1(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50503433(CHEMBL4462374 | US11274074, Comparative Example 19...)
Affinity DataIC50: 1.00E+5nMAssay Description:The method for inhibiting the expression of ANO1 (TMEM16A) of the present disclosure includes a step of inhibiting the expression of ANO1 (TMEM16A) i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
Go to US Patent

TargetAnoctamin-2(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50503433(CHEMBL4462374 | US11274074, Comparative Example 19...)
Affinity DataIC50: 1.00E+5nMAssay Description:The method for inhibiting the expression of ANO1 (TMEM16A) of the present disclosure includes a step of inhibiting the expression of ANO1 (TMEM16A) i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
Go to US Patent