BDBM50503275 CHEMBL4447740::US11203586, Example 10

SMILES Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)CNS(=O)(=O)N1CC1

InChI Key InChIKey=XREJHIYHGNFTCS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50503275   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50503275(CHEMBL4447740 | US11203586, Example 10)
Affinity DataIC50: 20nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) by NADPH depletion assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM50503275(CHEMBL4447740 | US11203586, Example 10)
Affinity DataIC50: 20nMAssay Description:The specific operation was as follows: 2.5 μl of the compound diluted in a 3-fold gradient was added to a 384-well plate, followed by adding 5 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2022
Entry Details
Go to US Patent