BDBM50503156 CHEMBL4468977

SMILES FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)-c1cccc(NC(=O)c2ccc(cc2)S(F)(=O)=O)c1

InChI Key InChIKey=IMNYDLPZFXMKCO-UHFFFAOYSA-N

Data  2 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50503156   

TargetMetabotropic glutamate receptor 2(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50503156(CHEMBL4468977)
Affinity DataKi:  112nMAssay Description:Displacement of [3H]JNJ-46281222 from human mGlu2 receptor expressed in CHOK1 cell membranes after 1 hr by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50503156(CHEMBL4468977)
Affinity DataEC50:  158nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in CHOK1 cell membranes assessed as increase in glutamate-induced [35S]GTPgammaS bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50503156(CHEMBL4468977)
Affinity DataKi:  166nMAssay Description:Displacement of [3H]JNJ-46281222 from human mGlu2 receptor expressed in CHOK1 cell membranes preincubated for 3 hrs followed by [3H]JNJ-46281222 addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed