BDBM50503155 CHEMBL4519152

SMILES CC(=O)C1=C(C(=O)N([C@@H]1C2CCCCC2)c3ccc(cc3F)Cl)O

InChI Key InChIKey=VQNLJXWZGVRLBA-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50503155   

TargetC-C chemokine receptor type 2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50503155(CHEMBL4519152)
Affinity DataIC50: 170nMAssay Description:Negative allosteric modulation of CCR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetC-C chemokine receptor type 5(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50503155(CHEMBL4519152)
Affinity DataIC50: 703nMAssay Description:Antagonist activity at human TEV cleavage site-linked CCR5 expressed in human U2OS cells harboring beta-lactamase reporter gene assessed as inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50503155(CHEMBL4519152)
Affinity DataIC50: 13nMAssay Description:Displacement of [3H]-CCR2-RA-[R] from wild type human CCR2 expressed in CHO cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetC-C chemokine receptor type 2(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50503155(CHEMBL4519152)
Affinity DataIC50: 12nMAssay Description:Displacement of [3H]-CCR2-RA-[R] from wild type human CCR2 expressed in CHO cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)