BDBM50503106 CHEMBL4537527

SMILES COc1ccc2c(cnn2c1)C(=O)Nc1ccc(NC(=O)c2nn(C3CCN(CC3)C(=O)NC(C)(C)C)c3ccc(F)cc23)cc1Cl

InChI Key InChIKey=QRHLGEHZPDSLFJ-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50503106   

TargetTyrosine-protein kinase CSK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50503106(CHEMBL4537527)
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged/GST-tagged CSK (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50503106(CHEMBL4537527)
Affinity DataIC50: 110nMAssay Description:Inhibition of His-tagged/GST-tagged LCK (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50503106(CHEMBL4537527)
Affinity DataIC50: 6nMAssay Description:Inhibition of CSK (unknown origin) using fluorescent labeled peptide as substrate in presence of ATP at Km concentration by caliper methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50503106(CHEMBL4537527)
Affinity DataEC50:  56nMAssay Description:Effect on ZAP70 phosphorylation in human Jurkat cells pre-incubated for 30 mins followed by anti-CD3/CD28 stimulation measured after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed