BDBM50503101 CHEMBL4469360

SMILES Cc1cc(ccc1NC(=O)c2cnn3c2ccc(c3)OC)NC(=O)c4c5ccccc5n(n4)C

InChI Key InChIKey=LXWXQRLCBZDGSZ-UHFFFAOYSA-N

Data  3 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50503101   

TargetTyrosine-protein kinase CSK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50503101(CHEMBL4469360)
Affinity DataIC50: 13nMAssay Description:Inhibition of CSK (unknown origin) using fluorescent labeled peptide as substrate in presence of ATP at Km concentration by caliper methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50503101(CHEMBL4469360)
Affinity DataIC50: 42nMAssay Description:Inhibition of His-tagged/GST-tagged CSK (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50503101(CHEMBL4469360)
Affinity DataEC50: >2.00E+4nMAssay Description:Effect on ZAP70 phosphorylation in human Jurkat cells pre-incubated for 30 mins followed by anti-CD3/CD28 stimulation measured after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50503101(CHEMBL4469360)
Affinity DataIC50: 42nMAssay Description:Inhibition of His-tagged/GST-tagged LCK (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)