BDBM50502759 CHEMBL4435596

SMILES Cc1cccc(c1)C2CCC(CC2)N3CCN(CC3)c4cccnc4

InChI Key InChIKey=QANXJBIOBLNORO-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50502759   

TargetTransient receptor potential cation channel subfamily V member 6(Human)
University of Bern

Curated by ChEMBL

LigandBDBM50502759(CHEMBL4435596)Copy SMILESCopy InChI

Affinity DataIC50: 320nMAssay Description:Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction of Cd2+ influx preincubated for 5 mins followed by CdCl2 addition by calciu...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/17/2021
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetTransient receptor potential cation channel subfamily V member 6(Human)
University of Bern

Curated by ChEMBL

LigandBDBM50502759(CHEMBL4435596)Copy SMILESCopy InChI

Affinity DataIC50: 50nMAssay Description:Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
3/23/2022
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL