BDBM50502716 CHEMBL4576494::US11440915, Example 11

SMILES Cc1cn(cn1)C12CCC(CC1)(CC2)Nc1nc2[C@H](CCCCn2n1)c1ccc(F)c(F)c1

InChI Key InChIKey=SHMFPLIJEKPQEZ-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50502716   

TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50502716(CHEMBL4576494 | US11440915, Example 11)
Affinity DataIC50: 39nMAssay Description:Inhibition of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
LigandPNGBDBM50502716(CHEMBL4576494 | US11440915, Example 11)
Affinity DataEC50:  39nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
Go to US Patent