BDBM50502709 CHEMBL4538936::US11440915, Example 8

SMILES Cc1cn(cn1)C12CCC(CC1)(CC2)Nc1nc2[C@@H](CCCCn2n1)c1cc(F)cc(Cl)c1

InChI Key InChIKey=BWQUDPIJOVHQMI-UHFFFAOYSA-N

Data  1 IC50  1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50502709   

TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Human)
Temple University

Curated by ChEMBL

LigandBDBM50502709(CHEMBL4538936 | US11440915, Example 8)Copy SMILESCopy InChI

Affinity DataIC50: 14nMAssay Description:Inhibition of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/17/2021
Entry Details Article
Copy Entry DOIPubMed
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TargetIsoform APP695 of Amyloid-beta precursor protein [K595N,M596L](Human)
Hoffmann-La Roche

US Patent

LigandBDBM50502709(CHEMBL4538936 | US11440915, Example 8)Copy SMILESCopy InChI

Affinity DataEC50:  14nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/19/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL