BDBM50502395 CHEMBL4561611

SMILES CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C#N)cc1

InChI Key InChIKey=FVCLKKTYTOAOQT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50502395   

TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50502395(CHEMBL4561611)
Affinity DataIC50: 2.00E+3nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL-17A secretion incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50502395(CHEMBL4561611)
Affinity DataIC50: 316nMAssay Description:Inverse agonist activity at human biotinylated HN-Avi-MBPS-TCS-RORC2 (258 to 518 residues) assessed as recruitment of SRC-1-derived coactivator measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed