BDBM50501650 CHEMBL4092036

SMILES COc1cccc(c1)-c1nn2c(Cn3nnc4ccccc34)nnc2s1

InChI Key InChIKey=RTNKFVVXJBHIGP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50501650   

TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501650(CHEMBL4092036)
Affinity DataIC50: 6.47E+3nMAssay Description:Inhibition of N-terminal 6His-tagged human DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) at preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50501650(CHEMBL4092036)
Affinity DataIC50: 6.42E+4nMAssay Description:Inhibition of DOT1L in human MV4-11 cells assessed as reduction in cell viability after 72 hrs by alamar blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed