BDBM50501398 CHEMBL4082978

SMILES C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2c(Cl)cc(F)cc2c(=O)n1-c1cc[nH]n1

InChI Key InChIKey=SAWISWWSHNTVLW-UHFFFAOYSA-N

Data  5 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50501398   

LigandPNGBDBM50501398(CHEMBL4082978)
Affinity DataEC50:  5.40nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human PC3 cells assessed as decrease in AKT1 phosphorylation at Ser473 after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM50501398(CHEMBL4082978)
Affinity DataEC50:  7.30nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human LNCaP cells assessed as decrease in AKT1 phosphorylation at Ser473 after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM50501398(CHEMBL4082978)
Affinity DataEC50:  5.70nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-415 cells assessed as decrease in AKT1 phosphorylation at Ser473 after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM50501398(CHEMBL4082978)
Affinity DataEC50:  3.40nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human ZR-75-1 cells assessed as decrease in AKT1 phosphorylation at Ser473 after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50501398(CHEMBL4082978)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM50501398(CHEMBL4082978)
Affinity DataIC50: 850nMAssay Description:Inhibition of human full length PI3K p110alpha/p85 alpha using PIP2/ATP as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM50501398(CHEMBL4082978)
Affinity DataEC50:  20nMAssay Description:Inhibition of PI3K p110beta in PTEN-deficient human PC3 cells assessed as decrease in AKT phosphorylation at ser473 after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM50501398(CHEMBL4082978)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human full length PI3Kgamma using PIP2/ATP as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM50501398(CHEMBL4082978)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human full length PI3K p110delta/p85 alpha using PIP2/ATP as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM50501398(CHEMBL4082978)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human PI3K p110beta/untagged recombinant full length human p85alpha expressed in baculov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed