BDBM50501032 CHEMBL3799870

SMILES Cc1cc(Nc2nc(Cl)cn([C@H](COC(=O)Nc3ccccc3)C3CC3)c2=O)c(C)nc1OC(F)F

InChI Key InChIKey=IBPPNXGXHLSEAN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50501032   

TargetCorticotropin-releasing factor receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50501032(CHEMBL3799870)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at CRF1 receptor in human Y79 cells assessed as inhibition of CRF-stimulated cAMP production preincubated for 30 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50501032(CHEMBL3799870)
Affinity DataIC50: 0.740nMAssay Description:Displacement of [125I]Tyr-ovine-CRF from CRF1 receptor in rat frontal cortex homogenate after 2 hrs by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed