BDBM50500970 CHEMBL3797601

SMILES CNC(=O)c1cc(Oc2ccc3nc(NC(=O)Nc4cc(cc(c4)C(F)(F)F)C(F)(F)F)sc3c2)ccn1

InChI Key InChIKey=OSDKCMJIQPHNPE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50500970   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50500970(CHEMBL3797601)
Affinity DataIC50: 566nMAssay Description:Inhibition of human C-RAF measured after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50500970(CHEMBL3797601)
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) measured after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50500970(CHEMBL3797601)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG assessed as reduction in channel current by automated patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed