BDBM50500949 CHEMBL3797793

SMILES O=C(Nc1nc(cs1)C#N)C1c2ccccc2Oc2ccccc12

InChI Key InChIKey=PWRHYRPHBVYXDN-UHFFFAOYSA-N

Data  4 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50500949   

TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataEC50:  710nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataEC50:  1.80E+3nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataEC50:  181nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as glutamate EC50 at 10 uM (Rvb = 983.4 nM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataEC50:  724nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataEC50:  182nMAssay Description:Positive allosteric modulation of human mGlu1 receptor assessed as glutamate pEC50 at 10 uM (Rvb = 6.007 +/- 0.076 No_unit)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50500949(CHEMBL3797793)
Affinity DataEC50:  1.86E+3nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as increase in glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed