BDBM50500349 CHEMBL3746388

SMILES Cn1cc(C(O)=O)c2ccc(cc12)N1CCC(CC1)OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1

InChI Key InChIKey=RPVDFHPBGBMWID-UHFFFAOYSA-N

Data  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50500349   

TargetProgesterone receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50500349(CHEMBL3746388)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at progesterone receptor (unknown origin) expressed in HEK293 cells assessed as transcriptional activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50500349(CHEMBL3746388)
Affinity DataEC50:  121nMAssay Description:Agonist activity at recombinant His-tagged human FXR ligand binding domain assessed as SRC-1 coactivator recruitment after 4 hrs by luminescence anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50500349(CHEMBL3746388)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at glucocorticoid receptor (unknown origin) expressed in HEK293 cells assessed as transcriptional activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50500349(CHEMBL3746388)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mineralocorticoid receptor (unknown origin) expressed in HEK293 cells assessed as transcriptional activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50500349(CHEMBL3746388)
Affinity DataEC50:  193nMAssay Description:Agonist activity at human FXR transfected in HEK293 cells assessed as transcriptional activity by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50500349(CHEMBL3746388)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at androgen receptor (unknown origin) expressed in HEK293 cells assessed as transcriptional activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50500349(CHEMBL3746388)
Affinity DataEC50:  110nMAssay Description:Agonist activity at GST-tagged human FXR LBD assessed as induction of biotinylated coactivator SRC-1 peptide recruitment measured after 2 hrs by stre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50500349(CHEMBL3746388)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human FXR expressed in HEK293 cells measured after 18 hrs by steady-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50500349(CHEMBL3746388)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells measured after 30 mins by cAMP substrate based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed