BDBM50499737 CHEMBL3741594

SMILES CC(C)(C)c1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C#N

InChI Key InChIKey=ZWNFXBJAGVYQIA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50499737   

TargetCathepsin S(Human)
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50499737(CHEMBL3741594)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant cathepsin S (unknown origin) using ZVVR-AMC fluorogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCaspase-3(Human)
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50499737(CHEMBL3741594)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant caspase 3 (unknown origin) using DEVD-AFC fluorogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 17(Human)
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50499737(CHEMBL3741594)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of USP17 in human HEK293T cells using fluorogenic substrate ub-rhodamine110 preincubated for 30 mins followed by substrate addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCaspase-8(Human)
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50499737(CHEMBL3741594)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant caspase 8 (unknown origin) using IETD-AFC fluorogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetLegumain(Human)
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50499737(CHEMBL3741594)
Affinity DataIC50: 71nMAssay Description:Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-MCA substrate measured every 2 mins for 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCathepsin B(Human)
Queen'S University Belfast

Curated by ChEMBL
LigandPNGBDBM50499737(CHEMBL3741594)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant cathepsin B (unknown origin) using Z-Leu-Arg-AMC fluorogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed