BDBM50499506 CHEMBL3741276

SMILES Cc1cc2cnn(CCO)c2cc1NC(=O)C1=CNC(=O)C[C@H]1c1ccc(F)cc1

InChI Key InChIKey=GARXFKOAJYYJSB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50499506   

TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499506(CHEMBL3741276)
Affinity DataIC50: 47nMAssay Description:Antagonist activity at P2X7R in human whole blood assessed as inhibition of LPS-induced IL-1beta production incubated for 30 mins followed by ATP add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499506(CHEMBL3741276)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed