BDBM50499502 CHEMBL3740237

SMILES COc1cc(Br)c(NC(=O)C2=CNC(=O)C[C@H]2c2cccc(F)c2)cc1OC

InChI Key InChIKey=IIOWXVRMSLPBEY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50499502   

TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499502(CHEMBL3740237)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499502(CHEMBL3740237)
Affinity DataIC50: 107nMAssay Description:Antagonist activity at P2X7R in human whole blood assessed as inhibition of LPS-induced IL-1beta production incubated for 30 mins followed by ATP add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed