BDBM50499489 CHEMBL3741681

SMILES CN1C=C([C@@H](NC1=O)c1ccc(F)cc1)C(=O)Nc1cc(ccc1C)-n1ccccc1=O

InChI Key InChIKey=GGVPRFJRROOJEI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50499489   

TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499489(CHEMBL3741681)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at P2X7R in human whole blood assessed as inhibition of LPS-induced IL-1beta production incubated for 30 mins followed by ATP add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50499489(CHEMBL3741681)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at human P2X7R expressed in BzATP-stimulated human 1321N1 cells incubated for 20 mins followed by BzATP stimulation measured ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed