BDBM50499153 CHEMBL3091673

SMILES COc1cc2CCN(CC(=O)Nc3ccc4NC(=O)\C(=C/c5cnc[nH]5)c4c3)Cc2cc1OC

InChI Key InChIKey=ZDNTZQGZVGAPGQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50499153   

TargetGlycogen synthase kinase-3 beta(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50499153(CHEMBL3091673)
Affinity DataIC50: 272nMAssay Description:Inhibition of GSK3beta (unknown origin) in presence of 10 uM ATP incubated for 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50499153(CHEMBL3091673)
Affinity DataIC50: 980nMAssay Description:Inhibition of PDK1 (unknown origin) incubated for 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50499153(CHEMBL3091673)
Affinity DataIC50: 274nMAssay Description:Inhibition of CHK1 (unknown origin) in presence of 10 uM ATP incubated for 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50499153(CHEMBL3091673)
Affinity DataIC50: 998nMAssay Description:Inhibition of PDK1 (unknown origin) in presence of 25 uM ATP incubated for 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50499153(CHEMBL3091673)
Affinity DataIC50: 884nMAssay Description:Inhibition of GSK3alpha (unknown origin) in presence of 10 uM ATP incubated for 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50499153(CHEMBL3091673)
Affinity DataIC50: 9.80E+4nMAssay Description:Inhibition of PDK1 (unknown origin) by SelectScreen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed