BDBM50498989 CHEMBL3734933

SMILES CO[C@H]1CCN(C[C@H]1F)c1nccc(Nc2cc3n(C(C)C)c(CO)nc3cn2)n1

InChI Key InChIKey=BJQBLOLTVCVLLZ-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50498989   

TargetEpidermal growth factor receptor(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50498989(CHEMBL3734933)
Affinity DataIC50: 290nMAssay Description:Inhibition of EGFR phosphorylation in human NCI-H1975 cells preincubated for 1 hr followed by stimulation with EGF for 8 mins by electrochemiluminesc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50498989(CHEMBL3734933)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR phosphorylation in human NCI-H292 cells preincubated for 1 hr followed by stimulation with EGF for 8 mins by electrochemiluminesce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50498989(CHEMBL3734933)
Affinity DataKi:  4.30nMAssay Description:Inhibition of human EGFR T790M/L858R double mutant using Fl-EEPLYWSFPAKKK-CONH2 as substrate preincubated for 30 mins followed by addition of substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50498989(CHEMBL3734933)
Affinity DataKi:  150nMAssay Description:Inhibition of human wild type EGFR using Fl-EEPLYWSFPAKKK-CONH2 as substrate preincubated for 30 mins followed by addition of substrate measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed