BDBM50498596 CHEMBL3609622

SMILES COc1cc(ccc1-n1cnc(C)c1)-c1cn(nn1)C1CCc2ccccc2NC1=O

InChI Key InChIKey=JEZPTRWWXISMOA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50498596   

TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498596(CHEMBL3609622)
Affinity DataIC50: 4.72E+3nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498596(CHEMBL3609622)
Affinity DataIC50: 390nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498596(CHEMBL3609622)
Affinity DataIC50: 1.76E+4nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed