BDBM50498588 CHEMBL3609633

SMILES COc1cc(ccc1-n1cnc(C)c1)-c1cn(nn1)[C@H]1C[C@H](C)c2ccccc2N(CC(F)(F)F)C1=O

InChI Key InChIKey=CCOCBFYPTBYLCA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50498588   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498588(CHEMBL3609633)
Affinity DataIC50: 6.68E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by MK-499 radioligand displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498588(CHEMBL3609633)
Affinity DataIC50: 40nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-42 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories Boston

Curated by ChEMBL
LigandPNGBDBM50498588(CHEMBL3609633)
Affinity DataIC50: 170nMAssay Description:Inhibition of gamma-secretase in human SH-SY5Y cells expressing beta-APP C-terminal fragment SPA4CT assessed as decrease of amyloid beta-40 level by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed