BDBM50498449 CHEMBL3596889

SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(Oc3cncc(n3)-c3ccc(F)cc3)c2)no1

InChI Key InChIKey=SRQQRYTWWRXHKL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50498449   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50498449(CHEMBL3596889)
Affinity DataIC50: 56nMAssay Description:Inhibition of RET (unknown origin) using ATP and 5FAM tagged TrkA peptide substrate incubated for 60 mins by microfluidics assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50498449(CHEMBL3596889)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of KDR (unknown origin) using ATP and 5FAM tagged TrkA peptide substrate incubated for 60 mins by microfluidics assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50498449(CHEMBL3596889)
Affinity DataIC50: 22nMAssay Description:Inhibition of human recombinant TrkA using ATP and 5FAM tagged TrkA peptide substrate incubated for 60 mins by microfluidics assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetEphrin type-B receptor 2(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50498449(CHEMBL3596889)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of EphB2 (unknown origin) using ATP and 5FAM tagged TrkA peptide substrate incubated for 60 mins by microfluidics assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed