BDBM50496848 CHEMBL3219778

SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)CC[C@H]2NC(=O)COCC(=O)NCCCCCCCNC(=O)COCC(=O)NC)ccc3O

InChI Key

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50496848   

TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50496848(CHEMBL3219778)
Affinity DataIC50: 38nMAssay Description:Antagonist activity at human mu opioid receptor expressed in Gqi5 transfected CHO cells assessed as inhibition of DAMGO-stimulated Ca2+ influx preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50496848(CHEMBL3219778)
Affinity DataIC50: 38nMAssay Description:Antagonist activity at human MOR transfected in CHO cells co-transfected with Gqi5 assessed as inhibition of DAMGO-induced calcium mobilization incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50496848(CHEMBL3219778)
Affinity DataKi:  9.20nMAssay Description:Displacement of [3H]-naloxone from human mu opioid receptor expressed in CHO cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50496848(CHEMBL3219778)
Affinity DataKi:  9.20nMAssay Description:Displacement of [3H]NLX from mouse MOR expressed in CHO cell membrane incubated for 90 mins by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed