BDBM50496800 CHEMBL3218036

SMILES COc1cc2ccccc2nc1COc1ccc(cc1)-c1nn(C)cc1-c1ccncc1

InChI Key InChIKey=DMJIVIUKEVILJD-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50496800   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50496800(CHEMBL3218036)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50496800(CHEMBL3218036)
Affinity DataIC50: 3.85E+3nMAssay Description:Inhibition of human recombinant PDE4A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50496800(CHEMBL3218036)
Affinity DataIC50: 8.27E+4nMAssay Description:Inhibition of human recombinant PDE3B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50496800(CHEMBL3218036)
Affinity DataIC50: 1.23E+5nMAssay Description:Inhibition of human recombinant PDE3A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50496800(CHEMBL3218036)
Affinity DataIC50: 3.43E+3nMAssay Description:Inhibition of human recombinant PDE4B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50496800(CHEMBL3218036)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to PDE10A in rat striatum homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed