BDBM50495392 CHEMBL3110290

SMILES Cn1cc(CCNC(=O)c2cc(=O)c3c(OCc4ccc(Br)cc4)cccc3o2)c2ccccc12

InChI Key InChIKey=QUTDVNWSRCEZBF-UHFFFAOYSA-N

Data  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50495392   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Bmssi Umr 5086 Cnrs/Universit£

Curated by ChEMBL
LigandPNGBDBM50495392(CHEMBL3110290)
Affinity DataEC50:  220nMAssay Description:Inhibition of ABCG2-mediated mitoxantrone efflux in mitoxantrone-selected human H460 cells after 30 mins by flow cytometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Bmssi Umr 5086 Cnrs/Universit£

Curated by ChEMBL
LigandPNGBDBM50495392(CHEMBL3110290)
Affinity DataEC50:  300nMAssay Description:Inhibition of ABCG2 (unknown origin)-mediated mitoxantrone efflux expressed in HEK293 cells after 30 mins by flow cytometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Bmssi Umr 5086 Cnrs/Universit£

Curated by ChEMBL
LigandPNGBDBM50495392(CHEMBL3110290)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human ABCG2 expressed in Sf9 insect cell membranes assessed as inhibition of quercetin-stimulated ATPase activity after 30 mins by colo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Bmssi Umr 5086 Cnrs/Universit£

Curated by ChEMBL
LigandPNGBDBM50495392(CHEMBL3110290)
Affinity DataEC50:  3.00E+8nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in HEK293 cells assessed as increase in mitoxantrone accumulation incubated for 30 mins by flow cytome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Bmssi Umr 5086 Cnrs/Universit£

Curated by ChEMBL
LigandPNGBDBM50495392(CHEMBL3110290)
Affinity DataEC50:  300nMAssay Description:Inhibition of ABCG2 (unknown origin)-mediated mitoxantrone effluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed