BDBM50494302 CHEMBL3086532

SMILES CCn1c(OC)nnc1[C@@H](C)NS(=O)(=O)c1ccc(F)c(Cl)c1

InChI Key InChIKey=CZEKSFTXHJDYSF-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50494302   

TargetSphingosine 1-phosphate receptor 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50494302(CHEMBL3086532)
Affinity DataIC50: 383nMAssay Description:Antagonist activity at human S1P1 receptor expressed in HEK293 cells assessed as inhibition of S1P-induced decrease in cAMP formation by [35S]GTPgamm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50494302(CHEMBL3086532)
Affinity DataKi:  249nMAssay Description:Antagonist activity at human S1P1 receptor expressed in HEK293 cells assessed as inhibition of S1P-induced decrease in cAMP formation by [35S]GTPgamm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50494302(CHEMBL3086532)
Affinity DataKi:  4.88E+3nMAssay Description:Inhibition of S1P3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50494302(CHEMBL3086532)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of S1P4 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50494302(CHEMBL3086532)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of S1P5 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed