BDBM50493263 CHEMBL2425924

SMILES COc1ccc(cc1)N(C)c1nc(C)nc2CCCc12

InChI Key InChIKey=GQRFTXWUCZQCHM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50493263   

TargetTubulin beta-3 chain(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50493263(CHEMBL2425924)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of beta3 tubulin overexpressed in human HeLa cells after 48 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50493263(CHEMBL2425924)
Affinity DataIC50: 16nMAssay Description:Inhibition of p-gp overexpressed in human SKOV3/M6-6 isogenic cells after 48 hrs by sulforhodamine B assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetTubulin beta chain(Pig)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50493263(CHEMBL2425924)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of pig brain tubulin assembly preincubated for 15 mins followed by GTP addition measured after 20 mins by spectrophotometric analysis in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed