BDBM50491759 CHEMBL2385755::US11401286, Example 270

SMILES CCCNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1

InChI Key InChIKey=SNGBOYNSHPJXDH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50491759   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50491759(CHEMBL2385755 | US11401286, Example 270)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [S133D](Human)
Tetra Discovery Partners

US Patent
LigandPNGBDBM50491759(CHEMBL2385755 | US11401286, Example 270)
Affinity DataIC50: 1.00E+3nMAssay Description:Assays are performed in 96-well plates in a total volume of 200 μl/well. Compounds are dissolved in dimethylsulfoxide (DMSO) and added to plates...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent

TargetIsoform 7 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Tetra Discovery Partners

US Patent
LigandPNGBDBM50491759(CHEMBL2385755 | US11401286, Example 270)
Affinity DataIC50: 1.00E+3nMAssay Description:Assays are performed in 96-well plates in a total volume of 200 μl/well. Compounds are dissolved in dimethylsulfoxide (DMSO) and added to plates...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent