BDBM50491279 CHEMBL2381969

SMILES OC(=O)[C@@H]1CCCC[C@@H]1C(=O)N1CCc2ccccc2[C@@H]1CN1C(=O)c2ccccc2C1=O

InChI Key InChIKey=LNENLABLFGGAFF-UHFFFAOYSA-N

Data  1 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50491279   

TargetNuclear factor erythroid 2-related factor 2(Human)
The State University of New Jersey

Curated by ChEMBL
LigandPNGBDBM50491279(CHEMBL2381969)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of Keap1-Nrf2 interaction in human HepG2 cells expressing ARE-bla assessed as activation of antioxidant response element by beta-lactamase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
The State University of New Jersey

Curated by ChEMBL
LigandPNGBDBM50491279(CHEMBL2381969)
Affinity DataKd:  1.00E+5nMAssay Description:Binding affinity to Keap1 kelch domain (unknown origin) by competitive SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
The State University of New Jersey

Curated by ChEMBL
LigandPNGBDBM50491279(CHEMBL2381969)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of Keap1-Nrf2 interaction in human U2OS cells assessed as Nrf2 nuclear translocation by beta-lactamase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed