BDBM50491238 CHEMBL2380451

SMILES COc1ccc(cc1)C1(N=C(N)n2nc(C)cc12)c1cccc(c1)-c1cncnc1

InChI Key InChIKey=RUUJDLSJAYXIRG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50491238   

TargetBeta-secretase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50491238(CHEMBL2380451)
Affinity DataIC50: 320nMAssay Description:Inhibition of human BACE1 (1-460) using CEVNLDAEFK as substrate preincubated for 10 mins prior to substrate addition measured after 15 mins by TR-FRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50491238(CHEMBL2380451)
Affinity DataIC50: 790nMAssay Description:Inhibition of BACE1-mediated soluble APPbeta release in human SH-SY5Y cells after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50491238(CHEMBL2380451)
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of human ERG expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed