BDBM50490974 CHEMBL2376665::US11964950, Compound Ref-2::US20230270730, Compound ref-2::US20240327355, Compound ref-2

SMILES CNS(=O)(=O)Nc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1

InChI Key InChIKey=XUMQXLFNDALQFY-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50490974   

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50490974(CHEMBL2376665 | US20230270730, Compound ref-2 | US...)
Affinity DataIC50: 364nMAssay Description:The test compound, CRAF (Thermo Fisher Scientific Inc.), MEK1 (Thermo Fisher Scientific Inc.) and ERK2 (Carna Biosciences, Inc.) were mixed in ATP-co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50490974(CHEMBL2376665 | US20230270730, Compound ref-2 | US...)
Affinity DataIC50: 12nMAssay Description:The test compound, BRAF (Eurofins Genomics KK.) and MEK1 (Thermo Fisher Scientific Inc.) were mixed in ATP-containing buffer and reacted for 90 minut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
Go to US Patent

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50490974(CHEMBL2376665 | US20230270730, Compound ref-2 | US...)
Affinity DataIC50: 22nMAssay Description:Inhibition of MEK1 (unknown origin) after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50490974(CHEMBL2376665 | US20230270730, Compound ref-2 | US...)
Affinity DataIC50: 364nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 3 below were evaluated by the fluorescent polarization method as described below.The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50490974(CHEMBL2376665 | US20230270730, Compound ref-2 | US...)
Affinity DataIC50: 12nMAssay Description:The BRAF-inhibiting activity of the compounds listed in Table 3 below was evaluated by the time-resolved fluorescence-fluorescence resonance energy t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2024
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50490974(CHEMBL2376665 | US20230270730, Compound ref-2 | US...)
Affinity DataIC50: 364nMAssay Description:The MEK1-inhibiting activity of the compounds listed in Table 6 below were evaluated by the fluorescent polarization method as described below. The t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM50490974(CHEMBL2376665 | US20230270730, Compound ref-2 | US...)
Affinity DataIC50: 12nMAssay Description:The BRAF-inhibiting activity of the compounds listed in Table 6 below was evaluated by the time-resolved fluorescence-fluorescence resonance energy t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
Go to US Patent