BDBM50490637 CHEMBL2338049

SMILES [H][C@]1(CCNC1)[C@H](Oc1c(F)ccc(F)c1Cl)c1ccccc1

InChI Key InChIKey=DPINDTNFGDXWLU-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50490637   

TargetSodium-dependent noradrenaline transporter(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50490637(CHEMBL2338049)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of human recombinant NET expressed in HEK293 cells assessed as inhibition of [3H]NE reuptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50490637(CHEMBL2338049)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant SERT expressed in HEK293 cells assessed as inhibition of [3H]5HT reuptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50490637(CHEMBL2338049)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human recombinant CYP2D6 by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50490637(CHEMBL2338049)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]WIN35428 from human recombinant DAT transfected in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed