BDBM50490600 CHEMBL2337602

SMILES [H][C@@]1(CCNC1)[C@@H](Oc1cccc(Cl)c1Cl)c1ccccc1

InChI Key InChIKey=MCHVXQNUHBOZIA-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50490600   

TargetCytochrome P450 2D6(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50490600(CHEMBL2337602)
Affinity DataIC50: 794nMAssay Description:Inhibition of human recombinant CYP2D6 by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50490600(CHEMBL2337602)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant SERT expressed in HEK293 cells assessed as inhibition of [3H]5HT reuptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50490600(CHEMBL2337602)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant NET expressed in HEK293 cells assessed as inhibition of [3H]NE reuptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50490600(CHEMBL2337602)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]WIN35428 from human recombinant DAT transfected in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed