BDBM50489343 CHEMBL2314607

SMILES [H][C@@]12COc3c(F)ccc(F)c3[C@@]1(CCO[C@H]2CCS(=O)(=O)CC(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1

InChI Key InChIKey=ZJPZMPHSVPDESN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50489343   

TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489343(CHEMBL2314607)
Affinity DataIC50: 22nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489343(CHEMBL2314607)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489343(CHEMBL2314607)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed