BDBM50489338 CHEMBL2314613

SMILES [H][C@@]12COc3c(F)ccc(F)c3[C@@]1(CCO[C@H]2CCS(C)(=O)=O)S(=O)(=O)c1ccc(F)c(F)c1

InChI Key InChIKey=JTAZCTOJXHUDNF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50489338   

TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489338(CHEMBL2314613)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489338(CHEMBL2314613)
Affinity DataIC50: 31nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50489338(CHEMBL2314613)
Affinity DataIC50: 14nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed