BDBM50486043 CHEMBL2204504

SMILES CCC(CC)Nc1cc(C(=O)NC2CC3CCC(C2)N3c2ccc(cn2)C(C)=O)c(C)cc1C(N)=O

InChI Key InChIKey=ICWIHFMEULLYAE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50486043   

TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486043(CHEMBL2204504)
Affinity DataIC50: 28nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486043(CHEMBL2204504)
Affinity DataIC50: 44nMAssay Description:Inhibition of Hsp90 in human NCI-N87 cells assessed as Her2 degradation after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed