BDBM50485599 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC ACID [NPPB]::CHEBI:34457

SMILES c1ccc(cc1)CCCNc2ccc(cc2C(=O)O)[N+](=O)[O-]

InChI Key InChIKey=WBSMIPAMAXNXFS-UHFFFAOYSA-N

Data  4 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50485599   

TargetMonocarboxylate transporter 4(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50485599(CHEBI:34457 | 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC A...)
Affinity DataIC50: 2.40E+5nMAssay Description:TP_TRANSPORTER: inhibition of L-Lactate uptake (L-Lactate:30mM) in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
LigandPNGBDBM50485599(CHEBI:34457 | 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC A...)
Affinity DataEC50:  600nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50485599(CHEBI:34457 | 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC A...)
Affinity DataEC50:  603nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50485599(CHEBI:34457 | 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC A...)
Affinity DataEC50:  320nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPannexin-1(Mouse)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50485599(CHEBI:34457 | 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC A...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of mouse Panx-1 expressed in Xenopus laevis oocytes assessed as inhibition of membrane current cells held at -60 mV and voltage steps to +...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50485599(CHEBI:34457 | 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC A...)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of 8-((4-chlorophenyl)amino)naphthalene-1-sulfonic acid binding to CDK2 (unknown origin) measured after 2 hrs by fluorescence based analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 2(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50485599(CHEBI:34457 | 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC A...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of 8-((4-chlorophenyl)amino)naphthalene-1-sulfonic acid binding to CDK2 (unknown origin) incubated for 2 hrs in presence of staurosporine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)