BDBM50484216 CHEMBL1822256

SMILES COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)c4ccccc4)c3F)cc12

InChI Key InChIKey=AQRCHNPFXKXZOD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50484216   

TargetSerine/threonine-protein kinase B-raf(Human)
Arraybiopharma

Curated by ChEMBL
LigandPNGBDBM50484216(CHEMBL1822256)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of full length B-Raf V600E mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Arraybiopharma

Curated by ChEMBL
LigandPNGBDBM50484216(CHEMBL1822256)
Affinity DataIC50: 22nMAssay Description:Inhibition of human recombinant BRAF V600E mutant using MEK1 as substrate measured after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed