BDBM50482173 4'-CYCLOPROPYL-5'-(5-(TRIFLUORO METHYL)PYRIDIN-2-YL SULFONYL)-4',5'-DIHYDROSPIRO[CYCLOPROPANE-1,6'-PYRAZOLO[4,3-C]PYRIDIN]-7'(1'H)-ONE (ENANTIOMERIC MIX)

SMILES FC(F)(F)c1ccc(nc1)S(=O)(=O)N1C(C2CC2)c2cn[nH]c2C(=O)C11CC1

InChI Key InChIKey=OQFIYWHZRVZQML-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50482173   

TargetPresenilin-1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50482173(4'-CYCLOPROPYL-5'-(5-(TRIFLUORO METHYL)PYRIDIN-2-Y...)
Affinity DataIC50: 6.21E+3nMAssay Description:Inhibition of gamma-secretase-mediated notch cleavage in human SNC cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50482173(4'-CYCLOPROPYL-5'-(5-(TRIFLUORO METHYL)PYRIDIN-2-Y...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of gamma-secretase-mediated notch cleavage in human SNC cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50482173(4'-CYCLOPROPYL-5'-(5-(TRIFLUORO METHYL)PYRIDIN-2-Y...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of gamma-secretase-mediated notch cleavage in human SNC cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed