BDBM50482 (5Z)-5-(3-bromo-4,5-dihydroxy-benzylidene)-2-(p-tolyl)-2-thiazolin-4-one::(5Z)-5-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one::(5Z)-5-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-2-(4-methylphenyl)-4-thiazolone::(5Z)-5-[[3-bromanyl-4,5-bis(oxidanyl)phenyl]methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one::5-(3-bromo-4,5-dihydroxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one::MLS000676730::SMR000298379::cid_5730111

SMILES Cc1ccc(cc1)C1=NC(=O)\C(S1)=C\c1cc(O)c(O)c(Br)c1

InChI Key InChIKey=MUQKQSJCEVWZCU-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50482   

LigandPNGBDBM50482((5Z)-5-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-...)
Affinity DataIC50: 767nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Nikolovska-Coleska, Univer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2011
Entry Details
PCBioAssay
TargetLarge T antigen(SV40)
Southern Research Specialized Biocontainment Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50482((5Z)-5-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-...)
Affinity DataEC50: >5.00E+4nMAssay Description:Southern Research's Specialized Biocontainment Screening Center (SRSBSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Librarie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2011
Entry Details
PCBioAssay
TargetTyrosine-protein kinase SYK(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50482((5Z)-5-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-...)
Affinity DataIC50: 120nMAssay Description:Inhibition of SYK (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 25 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2019
Entry Details Article
PubMed
TargetGenome polyprotein(DENV-2)
Queensland University of Technology

Curated by ChEMBL
LigandPNGBDBM50482((5Z)-5-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-...)
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibition of DENV2 NS2B-NS3 serine protease expressed using Benzoyl-Nle-Lys-Arg-Arg-AMC as substrate measured preincubated for 3 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGenome polyprotein(DENV-2)
Queensland University of Technology

Curated by ChEMBL
LigandPNGBDBM50482((5Z)-5-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-...)
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibition of Dengue Virus 1 recombinant NS2B-NS3 protease expressed in Escherichia coli using Bz-Nle-Arg-Arg-AMC as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Queensland University of Technology

Curated by ChEMBL
LigandPNGBDBM50482((5Z)-5-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-...)
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibition of Dengue Virus 2 recombinant NS2B-NS3 protease expressed in Escherichia coli using Bz-Nle-Arg-Arg-AMC as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Queensland University of Technology

Curated by ChEMBL
LigandPNGBDBM50482((5Z)-5-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-...)
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibition of Dengue Virus 3 recombinant NS2B-NS3 protease expressed in Escherichia coli using Bz-Nle-Arg-Arg-AMC as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Queensland University of Technology

Curated by ChEMBL
LigandPNGBDBM50482((5Z)-5-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-...)
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibition of Dengue Virus 4 recombinant NS2B-NS3 protease expressed in Escherichia coli using Bz-Nle-Arg-Arg-AMC as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed