BDBM50481378 CHEMBL595152

SMILES CC(C)(C)C#CC(CCC(F)(F)F)N1CCC(F)(F)[C@H](CC(O)=O)[C@H]1c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=IALNJMQIZBSHQV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50481378   

TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50481378(CHEMBL595152)
Affinity DataIC50: 390nMAssay Description:Inhibition of gamma secretase in human SHSY5Y cells expressing wild-type APP assessed as inhibition of intracellular amyloid beta-42 by electrochemil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50481378(CHEMBL595152)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of gamma secretase in human SHSY5Y cells expressing wild-type APP assessed as inhibition of intracellular amyloid beta-40 by electrochemil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed