BDBM50478375 CHEBI:86193::CHEMBL255682

SMILES C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@H](C(=O)OC(C)(C)C)c1ccccc1

InChI Key InChIKey=DWJXYEABWRJFSP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50478375   

TargetPresenilin-1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50478375(CHEBI:86193 | CHEMBL255682)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of [3H]L685458 from gamma-secretase in human THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50478375(CHEBI:86193 | CHEMBL255682)
Affinity DataIC50: 6.30nMAssay Description:Displacement of [3H]IN973 from gamma-secretase in human THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50478375(CHEBI:86193 | CHEMBL255682)
Affinity DataIC50: 500nMAssay Description:Inhibition of gamma secretase (unknown origin) mediated Notch signaling by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50478375(CHEBI:86193 | CHEMBL255682)
Affinity DataIC50: 115nMAssay Description:Inhibition of gamma secretase in human primary neuronal cells assessed as reduction in amyloid beta 40More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed