BDBM50477327 CHEMBL385554

SMILES CC(C)c1cc(C(C)C)c(c(c1)C(C)C)S(=O)(=O)n1c2ccc(Cl)cc2c2ccc(cc12)C(C)C(O)=O

InChI Key InChIKey=CXUNYDBSYPMDGW-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50477327   

TargetPresenilin-1(Human)
Darmstadt University of Technology

Curated by ChEMBL
LigandPNGBDBM50477327(CHEMBL385554)
Affinity DataIC50: 8.50E+3nMAssay Description:Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as reduction of Amyloid beta42 formation LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Darmstadt University of Technology

Curated by ChEMBL
LigandPNGBDBM50477327(CHEMBL385554)
Affinity DataIC50: 9.30E+3nMAssay Description:Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as increase in Amyloid beta-38 formation by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Darmstadt University of Technology

Curated by ChEMBL
LigandPNGBDBM50477327(CHEMBL385554)
Affinity DataIC50: 2.00E+4nMAssay Description:Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as reduction of Amyloid beta-40 formation LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Darmstadt University of Technology

Curated by ChEMBL
LigandPNGBDBM50477327(CHEMBL385554)
Affinity DataIC50: 8.50E+3nMAssay Description:Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as reduction of Amyloid beta-42 formation LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Darmstadt University of Technology

Curated by ChEMBL
LigandPNGBDBM50477327(CHEMBL385554)
Affinity DataIC50: 2.00E+4nMAssay Description:Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as reduction of Amyloid beta-40 formation LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Darmstadt University of Technology

Curated by ChEMBL
LigandPNGBDBM50477327(CHEMBL385554)
Affinity DataEC50:  9.30E+3nMAssay Description:Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as increase in Amyloid beta38 formation by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed