BDBM50476879 CHEMBL233172

SMILES CN1c2ccccc2C(=N[C@H](NC(=O)C2(CCCC2)C(=O)NCc2cc(F)cc(F)c2)C1=O)c1ccccc1

InChI Key InChIKey=OOEUBHQWKQXOAB-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50476879   

TargetPresenilin-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50476879(CHEMBL233172)
Affinity DataKi:  9.90nMAssay Description:Displacement of [3H]succinamide from gamma secretase in THP1 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50476879(CHEMBL233172)
Affinity DataIC50: 96nMAssay Description:Inhibition of gamma secretase in APP-transfected CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed